Inhibition of Subsets of G Protein-coupled Receptors by Empty Mutants of G Protein α Subunits in Go, G11, and G16
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چکیده
منابع مشابه
Inhibition of Subsets of G Protein-coupled Receptors by Empty Mutants of G Protein a Subunits
We previously reported that the xanthine nucleotide binding Goa mutant, GoaX, inhibited the activation of Gi-coupled receptors. We constructed similar mutations in G11a and G16a and characterized their nucleotide binding and receptor interaction. First, we found that G11aX and G16aX expressed in COS-7 cells bound xanthine 5*-O-(thiotriphosphate) instead of guanosine 5*-O(thiotriphosphate). Seco...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.275.1.71